TITLE: EVALUATION OF TUMOR IMMUNE INFILTRATE AS A DETERMINANT OF RESPONSE TO NEO-ADJUVANT LAPATINIB AND TRASTUZUMAB IN HER2-POSITIVE BREAST CANCER
De Angelis C1, Nagi C1, Hoyt C2, Linying2, Roman K2, Wang C2, Zheng Y2, Wang T1, Mao R1, Hilsenbeck SH1, Gutierrez C1, Wolff A3, Osborne, CK1, Rimawi MF1, Schiff R1
1Baylor College of Medicine, Houston, TX; 2PerkinElmer, Inc., Hopkinton, MA; 3The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD
Background: Dual HER2 blockade with LT without chemotherapy resulted in a substantial pathologic complete response (pCR) rate in HER2+ BC patients (pts) (TBCRC006). High levels of tumor infiltrating lymphocytes (TILs) at diagnosis have shown to be associated with greater benefit to T and chemotherapy in early-stage HER2+ BC pts. However the predictive value of TILs, TILs’ subsets, and other immune cells in pts receiving anti-HER2 treatment alone without chemotherapy is still unknown.
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