What’s New in Signals Screening 2.5

What’s New in Signals Screening 2.4.1

Signals Screening is an intuitive, configurable, and flexible screening workflow processing engine on top of the unparalleled data visualization and analysis capabilities of TIBCO Spotfire®.

Check out the latest improvements.

August 2020: PerkinElmer Signals 2.5 -

Signals Screening 2.5 continues the rapid progress on core screening and SPR capabilities to support scientists doing testing work throughout all stages of life science product R&D, from early-stage assay development all the way through late stage testing.

Core Screening capability improvements

  1. Curve Fitting flexibility. Signals Screening 2.5 completes the overhaul in the core curve fitting capability, enabling support for all types of assay development, physical characterization and in vitro ADME workflows. Our curve fit engine now supports global vs local curve fitting equations, incorporating other (non-graphed) data in curve fits, as well as the inclusion of any raw data into final results. Also, curve fit equations are now stored and managed by the Signals Screening meta-store, making it much easier to expand which equations are rolled out to scientists out of the box.

    Global Curve Fitting equations
    Fig 1: Global Curve Fitting equations
  2. New Curve Fit App – This App leverage significant improvements we have made to all Calculations Explorer workflows for curve fit selection and QA /QC. More curve fit options are now available, and data is auto matched to the curve fits wherever possible.

    New Curve Fitting App in Signals Screening 2.5
    Fig 2: New Curve Fitting App in Signals Screening 2.5
  3. Automated point exclusion – Signals Screening now includes an option to automatically exclude datapoints using the GESD algorithm to facilitate the ease with which large datasets can be processed in the system. This automatic point exclusion capability will greatly facilitate how customers are able to apply business rules to their screening data automatically.

  4. TERR dependency checking and facilitated R package installation – Users now can see all the R package dependencies for Signals Screening and download and install all required packages at the push of a button.

    TERR dependency Manager
    Fig 3: TERR dependency Manager
  5. SPR capability improvements
  6. Biacore S200 instrument support

  7. New Multi-cycle Kinetics App – this improved workflow provides a significantly improved UI with replicate grouping, sensogram coloring, and better Rmax and results reporting.

  8. New Solvent Correction App – provides functionality to correct any signal distortions caused by the solvent used in small molecule signal measurements. The app allows the selection of solvent correction regions in the solvent cycle, as well as the position on the reference to be used for the correction.

    Also included in this release are dozens of additional smaller bug fixes, feature enhancements, and incremental improvements.

    • Intuitive naming for data import tables
    • Data import app now previews the plate map results
    • Improved user workflow for curve QA/QC
    • Toggle-able plate view in Normalization App
    • Easier composition of final reporting tables
    • … and much more!

Signals Screening Product Page

April 2020: PerkinElmer Signals 2.4.1 +