What’s New in Signals™ Screening

What’s New in Signals Screening

Signals Screening is an intuitive, configurable, and flexible screening workflow processing engine on top of the unparalleled data visualization and analysis capabilities of TIBCO Spotfire® .

Check out the latest improvements.

August 2021: PerkinElmer Signals™ Screening 2.7 -

PerkinElmer Signals™ Screening 2.7

What’s New

Signals Screening 2.7 introduces In Vivo Apps, bringing support to a whole new wing of science: Pharmacokinetic experiments. The release also brings Signals Notebook integration, Calculation Explorer and Workflow improvements, as well as additional SPR instrument compatibility. With its many new features, we think you will find Release 2.7 a robust replacement for IDBS ActivityBase.

In Vivo Apps for Pharmacokinetics.

  • First full release of Apps focused on the process of running Pharmacokinetics (PK). These experiments are used to evaluate how much drug is in the blood stream of a treated organism.
  • Nine new Apps organize all the steps of a complicated In Vivo workflow: study definition, treatment planning, drug dose calculation, animal measurement, blood sampling, dose verification, final PK calculations, and QA/QC.
    In vivo apps for Pharmacokinetics
  • Includes a novel Sequence of Events view of an in vivo study that is a game-changer for how in vivo scientist can capture their data.

Signals Notebook Integration

  • Notebook properties are now included when opening a Signal Screening file from Signals Notebook allowing the context of the analysis to persist. These properties can be combined with the analysis and found easily later for traceability.
  • Tables defined by an administrator in Signals Notebook are now automatically available in Signals Screening when opening the file from the notebook. This allows easy transfer of data from notebook to analysis with no unnecessary copy and paste steps.

Calculation Explorer Visualization Layout Preserved

  • The chosen visual representation of your analysis is often critical to understanding your results. Arrange data the way you like and when you apply your calculation explorer template to the next data set you are presented with the results your way.

Workflows Improvements

  • Ensure proper analysis by locking parameters as desired.
  • Customize reports by configuring what items to include.
  • Access frequently used information easily from the Spotfire Library. Easily load saved tables to quickly integrate the information into your analysis.

Surface Plasmon Resonance (SPR)

  • Biacore 8K and Carterra LSA – SPR Data Import App expanded to include these two cutting edge instruments.
  • Dissociation only model – Additional kinetic model beyond standard 1:1 interaction with mass transport allows fitting just the dissociation component of the molecular interaction.

Further Details

Quick Start Guides

  • Release documentation now includes introductory guides for Screening, SPR, and the new In Vivo Apps.
  • Introduction to workflows allowing easier adoption and faster implementation.

Signals Notebook Integration

  • Notebook administrator defined properties are automatically brought in as a table when a Signal Screening file is opened from Signals Notebook and data is imported. These properties can then be combined with the analysis.
  • Signals Notebook administrator defined tables are now directly accessible in the Editable Data Grid App within Signals Screening when the file is opened from Signals Notebook.

Calculation Explorer

  • Visualization Improvements
    • Page Layout – Each page of your calculation explorer template is now preserved and can be viewed individually.
    • The order of detail visualization on each page are better preserved to maintain the analysis layout as built.
    • Y-axis single scale setting maintained.
    • Custom “Curve from Data Table” are saved in template allowing multiple curve fits that are brought together to be visualized together.
  • Iteratively Reweighted Least Squares (IRLS)
    • Adjustable sensitivity and limits on the number of excluded points.
    • Any point with a weight of zero is marked as excluded.
  • Curve fit parameters now have same number formatting as the corresponding axes.
  • Limit set of curves to fit via Boolean column.
  • Infrastructure
    • Metastores restart automatically when the hosting server reboots to ensure connectivity.
    • SPK file containing the R libraries can now be uploaded into Spotfire library ensuring app dependencies are met. Previously this was ensured on a per client basis.
  • Auto-exclusion column can now be included in calculation explorer template and applied automatically.
  • New alert whenever a change has occurred requiring recalculation of cascading data tables. Allows the review and exclusion of points without the recalculation of all fits slowing the process. Then when complete, all the curves are refit by updating the fitting results.
  • Multi-analyte (multi-parameter)
    • Method for use: Calculate a column based on a document property. Then create a Calculation Explorer and use the new option to parameterize by this column. A new column is created using the new parameters. The example below uses multiple analytes as the parameters. Run the calculation explorer on a new data set and this analysis step is completed automatically based on the new data in your selected column.


  • Faster exclusion of data and fitting.
  • Globally Unique IDentifiers (GUID) added for each curve to help with publication of data as well as traceability.
  • Individual parameters of Apps can now be locked so that they are not editable when executing the workflow.
  • The report setup can be edited to include/exclude which components to include in the report.
  • Table automatically selected in calculation explorer template when run within a workflow.
  • An empty template table can be loaded in the Editable Data Grid App to be filled in manually.
  • Reference tables from Spotfire Library are now accessible in the Editable Data Grid App.

Surface Plasmon Resonance (SPR)

  • Data Import App now supports Cytiva Biacore 8K and Carterra LSA instruments. The Biacore file (JSON) is exported from the Biacore Insight software. The Carterra LSA file (SPRData) is supported directly from the instrument.
  • Multi-Cycle Kinetics App now supports dissociation only kinetic model. Allows for fitting just the dissociation component of the molecular interaction. This model can be applied to the entire data set or just a subset of your data mixed with other fitting models if desired.
  • New Relative Potency App extends the functionality of the previous Parallel Line Analysis App while simplifying the analysis. It is now possible to go directly from Data Import to the new App using imported report points. Additionally, any dose response data can be analyzed as opposed to just SPR data. Finally, an editable data grid is incorporated to allow easier entry of comparison samples within the App as opposed to uploading a file.
March 2021: PerkinElmer Signals 2.6 +
December 2020: PerkinElmer Signals 2.5.1 +
August 2020: PerkinElmer Signals 2.5 +
April 2020: PerkinElmer Signals 2.4.1 +