What’s New in Signals™ VitroVivo

What’s New in Signals VitroVivo

Signals VitroVivo is an intuitive, configurable, and flexible workflow processing engine and data management system that includes the unparalleled data visualization and analysis capabilities of TIBCO Spotfire® .

Check out the latest improvements.

October 2021: PerkinElmer Introduces Signals™ VitroVivo 3.0 (formerly Signals Screening) -

PerkinElmer Signals™ VitroVivo 3.0 (formerly Signals Screening)


What’s New

Release 3.0 introduces a new name for the solution formerly known as Signals Screening: Signals VitroVivo. The new name highlights the breadth of the solutions provided from self-service flexible data analysis to scalable data management for in vitro and in vivo data. Signals VitroVivo does so much more than screening.

Not just a name change, this release brings Spotfire 11.4.0 LTS support along with all these new features:


In Vitro Apps

  • Improved introduction to Signals VitroVivo with ready-to-run workflows. Get comfortable with four built-in workflows using provided data sets, then easily modify or build your own workflow to analyze your data your way.
  • Over 70 built-in PRISM-like equations that can be deployed using Calculations Explorer Templates.
  • Over 40 requested feature enhancements throughout all the core Apps.
  • Signals Image Artist, the recently released next generation cell image analysis and management platform, is fully integrated with Signals VitroVivo.
  • New SPR Data Import App brings a simpler consistent user interface and a streamlined backend data model allowing the user to edit and annotate the imported data using the existing Editable Data Grid App.


In Vivo Apps

  • Custom attribution of Entities and Events.
  • Study Templates now supported.
  • Many updates throughout all the In Vivo Apps.


Signals Inventa Release 3.0 Highlights

  • Reminder: Signals VitroVivo includes Signals Inventa (formerly Signals Lead Discovery) and all its capabilities.
  • Dynamic pivot of the Assay Endpoint Result into the SAR table by any Spotfire-like expression enables simpler assay hierarchies and more flexible definition of the SAR Table.
  • ChemCharts 3.0 is a complete overhaul of this core component. Includes improved performance, new visualizations, and many UI improvements.
  • Replaceable datasets allow data updates to be almost instantaneous.


Further Details

Out-of-the-box workflows

  • Prebuilt workflows are now included for four standard assays. These workflows introduce Signals VitroVivo allowing easier adoption and faster implementation.
  • Users initiate the workflow and follow instructions to analyze provided data

  • These workflows can then be cloned and modified as desired for user specific use case. These can also be used as a basis for a new workflow the user can easily create using any of the Apps.
  • Users can now add instructions to their own workflows as well.


Over 70 Built-In Equations

  • Huge increase to the built-in curve fit options with the goal: If you can fit it in PRISM, you can fit it in Signals VitroVivo. Users can still add their own custom equations, but most likely you will find the desired equation in the provided list.
  • Complete documentation of all equations with associated references allow users to easily dig deeper into each equation and its function.


Over 40 improvement to the core screening apps

  • See list below for more information, but here are two with additional details:
    1. Confidence intervals can now be added to results in calculation Explorer App.
    2. Quality Assurance tab is now available for all calculation explorer templates and will persist while marking curves so that users can easily select and exclude or refit data.
  • Calculation Explorer Templates
    • Added additional built-in
    • Support for table visualization and sort order
    • Support for error bars
    • Support for visualizations using the fitting curve table
    • Support for calculations using the fitting curve table
    • Support for tooltips in scatterplots and bar charts
    • Support for “Add data from table”
    • Support for “Curve from table” using the main table
    • Improved support for complex calculation sequences
    • Properties and calculated columns can be kept when deleting the template
    • Nomenclature is more consistent
  • Calculation Explorer Curve Fitting
    • Thumbnail font can be configured
    • Table can be used in template calculations
    • Table can be used in template visualizations
    • Parameter estimation has improved
    • Parameters can be saved to file
    • Parameters can be set from saved file
    • ECx labels can be set to scientific notation
    • IRLS tags are more informative
    • IRLS cut-off can be specified for datapoint shape definition


Signals Image Artist Support

  • Support for PerkinElmer’s next generation cell image analysis and management platform, Signals Image Artist, while maintaining support for Columbus.



In Vivo

  • Study Templates now supported allowing each template to be configured for the specific experiment type.
  • PK Parameters App features have expanded significantly.


Surface Plasmon Resonance (SPR)

  • SPR Data Import App (NEW) brings a consistent user interface to align with the Screening Data Import App for ease of use. Data tables imported are reduced for simplicity and to allow new features moving forward.
  • One new feature enabled by the above SPR Data Import App (NEW) is the ability to edit and annotate the imported data. This is accomplished by using the existing Editable Data Grid App. This App allows the user to easily correct a concentration or enrich the data set by adding virtually any metadata to the analysis. The changes are applied to the Results Table and pushed to all necessary tables for downstream analysis.

August 2021: PerkinElmer Signals™ Screening 2.7 +
March 2021: PerkinElmer Signals 2.6 +
December 2020: PerkinElmer Signals 2.5.1 +
August 2020: PerkinElmer Signals 2.5 +
April 2020: PerkinElmer Signals 2.4.1 +