Applications of Cerenkov Luminescence for Brown Adipose Tissue Imaging and In Vivo Photochemistry

On Demand Webinar

Cerenkov luminescence imaging (CLI) utilizes luminescence generated from the + and - decay of radionuclides such as 18F and 131I. The spectrum of this radiation-luminescence consists of continuous wavelengths throughout the ultraviolet (UV) and visible spectrum (from 250 – 850nm), with the intensity distribution inversely proportional to the square of the wavelength. The Cerenkov Luminescence (CL) in both UV and visible ranges could be harnessed for different purposes. For the CL in visible range, it has been widely studied for tumor imaging.

This webinar demonstrated that the CL in this range could also be used beyond cancer research. The researcher showed that CLI from 18F-FDG could be utilized for in vivo imaging of brown adipose tissue (BAT), an important re-discovered target for obesity and diabetes studies. For the CLI in UV range (250 – 400nm), it could be used a replacement of ultraviolet (UV) light for in vivo photoactivation. The most important advantage of this replacement is its capability to overcome the depth limitation of UV light for in vivo photochemistry.

Presented By
Chongzhao Ran, Ph.D.
Molecular Imaging Laboratory, Massachusetts
General Hospital/Harvard Medical School


Original Broadcast Date: 30 July 2013

Duration: 48 minutes