Application Note: Tools for β-Arrestin Monitoring in Various Cells

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Highly specific tools for β arrestin monitoring in various cells

β-arrestin 1 and 2 play central roles in GPCR signaling pathways by regulating agonist-mediated GPCR signaling. Among their many roles, β-arrestins mediate both receptor desensitization and resensitization processes, act as a signaling scaffold for MAPK pathways, and target many receptors for internalization by recruiting GPCRs into adapter protein 2 complex 2 (AP-2) and clathrin-coated internalization pits. Different modes of arrestin-mediated internalization and signaling occur depending on the receptors, cell types, and expression level of β-arrestins and their partners. Furthermore, the extent of β -arrestin involvement appears to vary significantly depending on their expression, type, the receptors and ligands involved, and cell types.

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