Application Note: Cell Painting for Phenotypic Screening

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Cell Painting for Phenotypic Screening

Cell Painting is a powerful method which combines cell and computational biology to describe the behavior of cells phenotypically following treatment with chemical or genetic perturbagens. Since the first publications describing the technique, Cell Painting has been rapidly adopted for phenotypic drug discovery and basic research. Implementing the assay, however, comes with some challenges, ranging from the choice of cell model, appropriate labeling reagents, and optimizing instrumentation for detection, to making sense of up to thousands of features that are generated during data analysis. Here we describe how a cell painting assay can be set up on the Opera Phenix® Plus high-content screening system.

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