App Note

Enhance PROTAC Drug Discovery with AlphaLISA and HTRF® Kits

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A Bruton Tyrosine Kinase (BTK) case study

PROteolysis Targeting Chimeras (PROTACs) are one of the latest trending tools used in drug discovery.

This note compiles experiments carried out to characterize PROTAC compounds using Bruton Tyrosine Kinase (BTK) as a model on Ramos cells. Both AlphaLISA and HTRF technologies were used in biochemical and cell-based contexts.


Featured in this note:

• Assay principle and workflow

• Consistent results (data and graphs)

• Informative materials and methods, including references

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